Science

Vascular dysfunction, caused by factors such as aging, genetic risk and diseases, including hypertension and diabetes, leads to the toxic accumulation of fibrin deposits outside of blood vessels, which sparks chronic innate immune cell activation.

This unremitting, fibrin-induced inflammation caused by a lack of vascular integrity results in neuronal damage and is believed to be a central mechanism underlying neurodegeneration in the brain and retina.

Based on the work of world-renowned neurovascular & brain immunology expert and Therini Bio scientific founder Dr. Katerina Akassoglou, the Director of the Center for Neurovascular Brain Immunology and Professor of Neurology at the University of California, San Francisco and Gladstone Institutes, we are developing potentially first-in-class, fibrin-targeting immunotherapies for the treatment of severe retinal and neurological diseases driven by vascular dysfunction.